Synthesis, anticonvulsant (Chemo shock) activity of Isatin Mannich bases of quinazolone derivative

New N-methyl isatin [N-methyl -3-aryl -3H-quinazoline-4-one] derivatives 4(a-d) were synthesized and screened for anticonvulsant activity by strychnine,isoniazid (INH) and thiosemicarbazide induced chemo shock convulsion models. The neurotoxicity of the compounds was found by rotarod test. All the compounds were reported moderate protection of mice at 30 mg/kg at 0.5- 2 hr. in the entire test. No neurotoxicity was observed at the highest dose of 300 mg/kg for all the compounds.