Comparative wound healing activity of different marketed formulation in albino wistar rats

The present study was aimed to compare in-vivo topical wound healing activity of different marketed formulation in wistar rats by excision and incision wound models. Three different marketed formulations were chosen to have different formulae. The animals were grouped into; group I (left untreated) considered as control, group II (Povidone Iodine 5% w/w, once daily), Group III (Mupirocin 2% w/w, once daily), group IV (Povidone Iodine 5% w/w + Mupirocin 2% w/w in 1:1 ratio, once daily). The healing effect of the formulations was accessed as excision wound area measurement, Percentage wound contraction and epithelialization period in the excision wound model, however wound breaking strength was accessed in the incision wound model. The results of the present study revealed that, animals treated with Mupirocin 2% ointment shows significant wound healing potential in comparison to control and other treatment groups. Mupirocin showed a significant and faster rate of wound contraction (p<0.001) as compared with control with the minimum epithelialization period as compared to other groups. Mupirocin also showed significant tensile strength (p<0.001) as compared to control. So the study concludes that mupirocin might be a drug of choice for better healing. Such type of comparative study is also further can be done on a large scale to find out more better significant results.