The Interleukin-1 Family: A Key Regulator in the Pathogenesis of PsoriasisJournal: Austin Journal of Clinical Immunology (Vol.1, No. 5)
Publication Date: 2014-11-03
Authors : Yelin Wu; Hongquan Li; Ziwei Jiang; Yuping Lai;
Page : 1-5
Keywords : IL-1 family; IL-17; IL-17/IL-1 axis; Psoriasis;
Interleukin-1 (IL-1) family members, as most potent molecules of the innate immune system, are key regulators of multiple inflammatory diseases. The family includes seven ligands with agonist activity (IL-1α and IL-1β, IL-18, IL- 33, IL-36α, IL-36β, IL-36γ), three receptor antagonists (IL-1Ra, IL-36Ra, IL- 38), and one anti-inflammatory cytokine (IL-37). Most of these cytokines are abundantly expressed in skin under the regulation of IL-17 and act on innate immune cells to influence their survival and function. This review provides an overview of all the members of the IL-1 family and its potential regulatory roles in the pathogenesis of psoriasis.
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