Review on Benzothiazole Includiing Synthetic and Phamacological Activity
Journal: Journal of Pharma Research (Vol.1, No. 4)Publication Date: 2012-12-05
Authors : Ashwin G. Patel Kishor N. Raval Shivani P. Patel Kaushik S. Patel; Snehal V. Patel;
Page : 1-4
Keywords : Benzothiazole; Synthesise; Antibacterial Activity; Anti Cancer Study.;
Abstract
Five series of thiourea derivatives bearing benzothiazole moiety were efficiently synthesized and evaluated for antimicrobial and anticancer activities. The results indicated that the compounds possessed a broad spectrum of activity against the tested microorganisms and showed higher activity against fungi than bacteria. Compounds 1b, 2b, 3b, 4b and 5b exhibited the greatest antimicrobial activity. Preliminary study of the structure?activity relationship revealed that electronic factors in benzothiazole rings had a great effect on the antimicrobial activity of these compounds. In preliminary MTT cytotoxicity studies, the thiourea derivatives (2d, 5c and 5d) were found most potent. In MCF-7 and HeLa cells, the IC50 values were observed in the range of 18?26 mM and 38?46 mM, Respectively.
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