EXPRESSION OF INTERCELLULAR ADHESION MOLECULE (ICAM-1) ON LYMPHOCYTES AND THE LEVELS OF PRO- AND ANTIINFLAMMATORY CYTOKINES IN PATIENTS WITH PYELONEPHRITIS

The aim of this work is to investigate the level of mononuclear cells, expressing intercellular adhesion molecule (CD54+), pro- (IL-1, TNF-a) and antiinflammatory (IL-4, TGF-в) blood cytokines in the patients with pyelonephritis PN, to determine the peculiarities in acute and chronic its course. Materials and methods. The immuno-enzymic method ELISA and the corresponding test-systems (“Diaclone”, “DRG”) were used to study the levels of blood cytokines and immuno-fluorescent with “Coltage” (USA) – the level of CD54+-cells. Results. It has been demonstrated that CD54+-lymphocytes, IL-1, TNF-a, IL-4 and TGF-ft in blood were increased in patients with acute and chronic pyelonephritis, compared with healthies. The number of lymphocytes expressing CD54 and the level of TGF-ft were higher in patients with chronic pyelonephritis. Conclusion. The high level of cytokines and CD54+-lymphocytes in blood ofpatients confirm their important role in immunogenesis of pyelonephritis, the interrelation is especially interesting between CD54+-cells and TGF-ft in chronic process.