FISIOPATOLOGIA DA COVID-19: REPERCUSSÕES SISTÊMICAS

COVID-19 is caused by the entry of SARS-CoV-2 into the tissues by means of the enzyme ACE2, which results in a systemic impairment, since the receptor responsible for the entry of the virus can be found in several organs. Thus, in view of the current global scenario generated by the high infectivity of the disease, an in-depth study on the pathophysiology of COVID-19 is necessary in order to provide a greater understanding of the theme. The study aimed to differentiate SARS-CoV-2 to other types of human coronaviruses, including virulence factors, as well as to evaluate the mechanisms of entry and adhesion in the cell, systemic repercussions of infection and important clinical outcomes. The study presents a qualitative approach, carried out in September of 2020. It was concluded that the virus responsible for the disease has important characteristics in the involvement of several human tissues.