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Journal: Indo American Journal of Pharmaceutical Sciences (IAJPS) (Vol.03, No. 07)

Publication Date:

Authors : ; ; ;

Page : 750-755

Keywords : Frovatriptan; HPMC E5; Maltodextrin; Mannitol; Propylene glycol; Aspartame.;

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In the present research work Frovatriptan drug was formulated as Fast dissolving Thin oral films by solvent casting method. Triptans are a class of anti migraine drugs which are formulated to give rapid relief from migraine attacks. Previously prepared in the form of tablets which has certain disadvantages so are formulated as films which disintegrate rapidly within in seconds in the mouth without need of water. The films were prepared by employing Frovatriptan drug, Hydroxy Proipyl Methyl Cellulose (HPMC E5) as polymer, Isopropyl alcohol was employed as solvent, Propylene glycol as plasticizer, Mannitol as diluents and aspartame as sweetening agent. The films were evaluated for parameters like Weight uniformity, Morphological properties Thickness uniformity, Folding endurance, Surface pH, Drug content uniformity test, In-vitro disintegration test, In-vitro dissolution studies which were found to be satisfactory. Among all the formulations F8 has found to be the best formulation with a disintegration time of 12sec and 100% of cumulative drug release within in 20min. Thus it indicates that Frovatriptan is highly suitable to be formulated as Fast dissolving thin oral films for their rapid release and immediate treatment of migraine attack. Keywords: Frovatriptan, HPMC E5, Maltodextrin, Mannitol, Propylene glycol, Aspartame.

Last modified: 2016-07-24 00:31:41