LIQUISOLID COMPACT TECHNOLOGY: A NOVEL APPROACH FOR ENHANCEMENT OF DISSOLUTION AND BIOAVAILABILITY OF KETOPROFEN

Liquid solid compact technology is a novel approach to enhance bioavailability of a BCS class II drug by improving its solubility and dissolution rate of the drug. Liquisols are the formulations which make the solid drug transforms into its solubilized state and further it will be converted into a free flowing powder with good flow properties that is suitable for per-oral administration. Ketoprofen is a BCS class II drug with poor aqueous solubility and limited its bioavailability. In the present study, liquid solid technique is used to enhance the bioavailability of Ketoprofen. Liquisols of Ketoprofen were prepared using polyethylene glycol (PEG) 400 as liquid vehicle, Avicel pH 102 as carrier and Aerosil 200 as coating material. All the nine formulations were prepared using 30%, 40% and 50% concentration of drug in liquid vehicle and a Carrier: Coating ratios of 10:1, 15:1, 20:1. All the formulations were subjected for preformulation studies for drug polymer compatibility, saturation solubility studies. The unit doses were calculated and the flow properties of the powder were estimated using Carr’s index, Hausner’s ratio and angle of repose. The final preparations were filled in hard gelatin capsules and subjected for dissolution studies using pH 7.4 phosphate buffer in order to find out the optimized formula. Finally, the optimized formula was compared with a marketed tablet to study the enhancement in bioavailability and the results showed a quick release of drug from Liquisols. Keywords: Ketoprofen, Liquisols, Mathematical model, liquid load factor, Solubility, Dissolution, Bioavailability