CHRONIC FORCED SWIMMING INDUCED STRESS ALTERS BEHAVIOURAL, HISTOLOGICAL AND ANTI-OXIDANT STATUS
Journal: Indian Drugs (Vol.54, No. 6)Publication Date: 2017-06-30
Authors : Prusty S. K.; Pati A. K.; Subudhi B. B.; Sahu P. K.;
Page : 58-64
Keywords : Stress; Animal model; Forced swimming; neurodegeneration; behavior; histology;
Abstract
Exposure to chronic stress is an important factor of neurodegeneration. Forced swimming test is a common model for chronic stress which needs validation in terms of duration of exposure and correlation of behavioural, histological and anti-oxidant status. Adult wistar albino rats (150-200 g) of both sexes were divided into two groups. Group I treated as control and Group II animals were subjected to forced swimming test for 30 minutes daily. On different days (0, 3,7,15 and 30) effect on behavioural, histological and anti-oxidant status was evaluated. Swimming stress of 30 minutes daily for 15 days significantly (p
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