MORPHOFUNCTIONAL CHANGES IN HISTIONIC COMMUNITY OF LIVER IN CHRONIC CADMIUM INTOXICATION

Cadmium belongs to the high-toxic elements having a wide spread occurrence in environment. The ability of cadmium to long-term accumulation in living organisms puts it by nature of impact on a human body, beyond competition among metals-ecotoxicants [4, 5, 6]. It is known that cadmium passing to human body and animals generally with food and water. The special part in the process of detoxication of harmful substances passing to an organism, is assigned to liver as it provides binding and deactivation of toxic substances of an endogenous and exogenous origin, including salts of heavy metals [7, 8]. As it is interconnected by formation of high-toxic intermediates and initiation of free radical processes, during a metabolism it is most probable that body could be injured [9, 10, 11]. The maintenance of structure functional homeostasis, providing cells of liver pulp with energy-related and plastic material, and preservative and protective role of its structures at penetration of damaging agents occur, in the so-called, histionic community which can be considered as the module of the microvasculature caring a certain complex of a pulp and between its structures there is a close connection [1, 2, 3]. Therefore, the objective of the work was the research of structure functional diseases in histionic community of a liver in cadmium intoxication that is not yet enough studied and has considerable academic and practical interest.