GENETIC FACTOR OF VENOUS THROMBOSIS IN TERMS OF INDIVIDUALIZED APPROACH TO TREATMENT OF PATIENTS WITH VENOUS THROMBOEMBOLIC COMPLICATIONS

In the article, the literature survey is presented based on analysis of the data of Russian and international authors concerning study of the genetic factors of venous thrombosis. One of the main tasks of personalized medicine is determination of the individual risk for development of venous thromboembolic complications on the basis of molecular-genetic and other biomarkers. Before that, doctors were oriented, besides the clinical diagnosis, at the only accessible individual characteristics of patients: gender, age, body mass, family history, comorbid and past diseases, biochemical parameters, risk of hereditary morbidity. The priority task in this direction is identification of significant genetic variations that determine risks for development of venous thromboembolism. The individual approach takes into account the genetic program of an individual, clinical, demographic, laboratory and instrumental predictors of the response to the conducted treatment, and risks for probable complications. It also includes analysis of metabolism of the medical drugs, immune response that largely influence specificity of the response of an organism as a whole to a medical drug; besides, it includes monitoring of treatment through biomarkers. Development of personalized medicine may be an important factor permitting to optimize strategy of individual treatment.