Influence of solvent extraction on phenolic content, antioxidant and anti-inflammatory activities of aerial parts extract from Algerian Artemisia Herba-alba

Artemisia Herba-alba is a commonly consumed medicinal and culinary herb in Algeria. This current study aimed to obtain the proper solvent for extracting bioactive compounds from Artemisa Herba-alba guided by phenolic content, flavonoid content, proanthocyanidins, antioxidant and anti-inflammatory activity. The results showed that ethyl acetate extract of exhibited the highest phytochemical composition (total phenolic content 92.29±3.25 mg GAE/g W, total flavonoids content 61.24±2.04 mg RT/g DW and proanthocyanidins 25.47±0.95 mg CAE/g DW), while butanol extract (BE), water extract (WE) and the minimum value in chloroform extract (CE). The best DPPHÿ scavenging capacity (IC50= 36.85±1.17 ?m/mL), beta-carotene (23.83± 0.53) and ferric reducing power (IC50= 14.71± 0.51 ?m/mL) were observed in EAE followed by BE. Our study also revealed the high anti-inflammatory potential of EAE, BE, WE and CE. Ethyl acetate can be an efficient solvent for extracting antioxidants from Artemisa Herba-alba based on this study. All these biological activities are well correlated with the phenolic contents of these extracts. These findings demonstrate the remarkable potential of these plants as valuable source of antioxidants with exhibit original and interesting anti-inflammatory and anticancer capacities.