Dissolution Enhancement of Diclofenac Sodium by Self Emulsifying Technique

The present investigation was aimed to dissolution enhancement of diclofenac sodium by using Self emulsifying Technique using lemon oil as a oil, Tween 80,Tween 20,as a surfactant, span 20, span 80 as a co solvent etc. using in this technique. Pellets are prepared by Extrusion process. The solid self-emulsifying drug delivery systems were characterized by particle size analysis, Drug content, in vitro and in vivo pharmacokinetic studies. .Highest dissolution is found in f 9 formulation in Phosphate buffer Ph 6.8 as compared to other formulation.