Reducing the Global Burden of Dengue: Steps toward Preventive Methods

The epidemiological data for Dengue has validated the alarming situation of dengue across the world, which in turn brings a huge population at the risk of dengue infection. Dengue virus (DENV) has ourserotypes, thus the generation of a single therapeutic to target all the 4 viruses can be challenging. The severity of this infection ranges from dengue fever and in extreme condition causes fatal haemorrhagic fever. Significant methods for preventing dengue transmission were vector control and dengue vaccination, both these methods will help in minimizing the quantum of disease. Novel techniques like using Wolbachia, Entomopathogenic fungi and genetically modified mosquitoes are successfully advancing in the direction for eliminating the Aedes aegypti and Aedes albopictus population. Moreover, clinical trials of dengue vaccines such as CYD-TD, LATV Δ 30 and DENVax are also showing promising results.